mimsys® platform candidates demonstrate design features and characteristics which provide unique and highly competitive advantages over alternative biomaterial technologies available for regenerative medicine applications:
Our experience with biomaterial development enables us to efficiently design, test and iterate on biomaterial candidates for specific use-cases and target product profiles. For each application, Stemmatters establishes a well-defined and structured development roadmap aimed at providing candidates for successful clinical development.
Stemmatters is strongly committed to expand product development collaborations with third parties. Our company is open to different collaboration frameworks. We encourage you to engage with us and begin the conversation.
STM-148B possesses important features that no other cartilage repair product in the market currently provides, offering significant competitive and usability advantages that benefit the patient as well as value based healthcare practices:
P. Costa, D. Learmonth, D. Gomes, M. Cautela, A. Oliveira, R. Andrade, J. Espregueira-Mendes, T. Veloso, C. Cunha and R. Sousa. Mussel-Inspired Catechol Functionalisation as a Strategy to Enhance Biomaterial Adhesion: A Systematic Review. Polymer, 2021. doi: 10.3390/polym13193317.
D. Learmonth, P. Costa, T. Veloso, C. Cunha, M. Cautela, C. Correia, M. Vallejo and R. Sousa. Synthesis and Biological Evaluation of a Bioinspired, Tissue-Adhesive Gellan Gum-Based Hydrogel Designed for Minimally Invasive Delivery and Retention of Chondrogenic Cells. Biomater. Sci., 2020. doi: 10.1039/D0BM00286K.
C. Cunha, R. Andrade, T. Veloso, D. Learmonth, J. Espregueira‑Mendes and R. Sousa. Enhanced microfracture using acellular scaffolds improves results after treatment of symptomatic focal grade III/IV knee cartilage lesions but current clinical evidence does not allow unequivocal recommendation. Knee Surg. Sports Traumatol. Arthrosc., 2020. doi: 10.1007/s00167-019-05832-5.
L. Rocha, E. Gomes, J. Afonso, S. Granja, F. Baltazar, N. Silva, M. Shoichet, R. Sousa, D. Learmonth and A. Salgado. In vitro evaluation of ASCs and HUVECs co-cultures in 3D biodegradable hydrogels on neurite outgrowth and vascular organization. Front. Cell Dev. Biol., 2020. doi: 10.3389/fcell.2020.00489.
G. Soares, D. Learmonth, M. Vallejo, S. Davila, P. Gonzalez, R. Sousa and A. Oliveira. Supercritical CO2 technology: The next standard sterilization technique? Materials Science & Engineering, 2019, C99, 520–540. doi: 10.1016/j.msec.2019.01.121
C. Vilela, C. Correia, A. Morais, T. Santos, A. Gertrudes, E. Moreira, A. Frias, D. Learmonth, P. Oliveira, J. Oliveira, R. Sousa, J. Espregueira-Mendes and R. Reis. In vitro and in vivo performance of methacrylated gellan gum hydrogel formulations for cartilage repair. J. Biomed. Mater. Res. A., 2018, 106(7), 1987-1996. doi: 10.1002/jbm.a.36406.
C. Vilela, C. Correia, J. Oliveira, R. Sousa, J. Espregueira-Mendes and R. Reis. Cartilage Repair Using Hydrogels: A Critical Review of in vivo Experimental Designs. ACS Biomater. Sci. Eng., 2015, 1(9), 726-739. doi: 10.1021/acsbiomaterials.5b00245.
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